High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries

Immunotoxins are an important class of antibody-based therapeutics. The potency of the immunotoxins depends on the antibody fragments as the guiding modules targeting designated molecules on cell surfaces. Phage-displayed synthetic antibody scFv libraries provide abundant antibody fragment candidate...

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Vydáno v:Sci Rep
Hlavní autoři: Hou, Shin-Chen, Chen, Hong-Sen, Lin, Hung-Wei, Chao, Wei-Ting, Chen, Yao-Sheng, Fu, Chi-Yu, Yu, Chung-Ming, Huang, Kai-Fa, Wang, Andrew H.-J., Yang, An-Suei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994030/
https://ncbi.nlm.nih.gov/pubmed/27550798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31878
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