A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Grassilli, E, Pisano, F, Cialdella, A, Bonomo, S, Missaglia, C, Cerrito, M G, Masiero, L, Ianzano, L, Giordano, F, Cicirelli, V, Narloch, R, D'Amato, F, Noli, B, Ferri, G L, Leone, B E, Stanta, G, Bonin, S, Helin, K, Giovannoni, R, Lavitrano, M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994017/
https://ncbi.nlm.nih.gov/pubmed/26804170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.504
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