Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation

Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A, a PDE isoform with 40–100-...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Vang, Amanda G., Basole, Chaitali, Dong, Hongli, Nguyen, Rebecca K., Housley, William, Guernsey, Linda, Adami, Alexander J., Thrall, Roger S., Clark, Robert B., Epstein, Paul M., Brocke, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993990/
https://ncbi.nlm.nih.gov/pubmed/27601994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00259
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