PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER

BACKGROUND: Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE...

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Hlavní autoři: Vang, Amanda G., Ben-Sasson, Shlomo Z., Dong, Hongli, Kream, Barbara, DeNinno, Michael P., Claffey, Michelle M., Housley, William, Clark, Robert B., Epstein, Paul M., Brocke, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918507/
https://ncbi.nlm.nih.gov/pubmed/20711499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012011
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