Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades

Colonic enterocytes form a rapidly renewing epithelium and barrier to luminal antigens. During renewal, coordinated expression of the claudin family of genes is vital to maintain the epithelial barrier. Disruption of this process contributes to barrier compromise and mucosal inflammatory diseases. H...

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Bibliografiske detaljer
Udgivet i:Tissue Barriers
Main Authors: Lili, Loukia N., Farkas, Attila E., Gerner-Smidt, Christian, Overgaard, Christian E., Moreno, Carlos S., Parkos, Charles A., Capaldo, Christopher T., Nusrat, Asma
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993572/
https://ncbi.nlm.nih.gov/pubmed/27583195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21688370.2016.1214038
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