Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Mediator, an evolutionarily conserved multi-protein complex consisting of about 30 subunits, is a key component of the polymerase II mediated gene transcription. Germline deletion of the Mediator subunit 1 (Med1) of the Mediator in mice results in mid-gestational embryonic lethality with development...

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Publicado en:PLoS One
Autores principales: Jia, Yuzhi, Chang, Hsiang-Chun, Schipma, Matthew J., Liu, Jing, Shete, Varsha, Liu, Ning, Sato, Tatsuya, Thorp, Edward B., Barger, Philip M., Zhu, Yi-Jun, Viswakarma, Navin, Kanwar, Yashpal S., Ardehali, Hossein, Thimmapaya, Bayar, Reddy, Janardan K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993490/
https://ncbi.nlm.nih.gov/pubmed/27548259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160755
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