Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac

This study demonstrates the effectiveness of a peptide shuttle in delivering diclofenac into and through human epidermis. Diclofenac was conjugated to a novel phenylalanyl-N-methyl-naphthalenylalanine-derived diketopiperazine (DKP) shuttle and to TAT (a classical cell penetrating peptide), and topic...

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Udgivet i:PLoS One
Main Authors: Mohammed, Yousuf, Teixidó, Meritxell, Namjoshi, Sarika, Giralt, Ernest, Benson, Heather
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993479/
https://ncbi.nlm.nih.gov/pubmed/27548780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160973
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