A novel resistance mutation in eccC(5) of the ESX-5 secretion system confers ofloxacin resistance in Mycobacterium tuberculosis

BACKGROUND: Fluoroquinolone resistance in Mycobacterium tuberculosis is often conferred by DNA gyrase mutations. However, a substantial proportion of fluoroquinolone-resistant M. tuberculosis isolates do not have such mutations. METHODS: Ofloxacin-resistant and lineage-matched ofloxacin-susceptible...

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Vydáno v:J Antimicrob Chemother
Hlavní autoři: Eilertson, Brandon, Maruri, Fernanda, Blackman, Amondrea, Guo, Yan, Herrera, Miguel, van der Heijden, Yuri, Shyr, Yu, Sterling, Timothy R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992850/
https://ncbi.nlm.nih.gov/pubmed/27261264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw168
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