Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins

Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more. As this complex array of tools arises a distinct set of challenges is rarely encountered in the development of small molecu...

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Detalles Bibliográficos
Publicado en:J Immunol Res
Autores principales: Smith, Alison, Manoli, Hugh, Jaw, Stacey, Frutoz, Kimberley, Epstein, Alan L., Khawli, Leslie A., Theil, Frank-Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992793/
https://ncbi.nlm.nih.gov/pubmed/27579329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2342187
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