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β8 integrin expression and activation of TGF-β by intestinal dendritic cells is determined by both tissue microenvironment and cell lineage
Activation of TGF-β by dendritic cells (DCs) expressing αvβ8 integrin is essential for the generation of intestinal regulatory T cells (Tregs) that in turn promote tolerance to intestinal antigens. We have recently shown that αvβ8 integrin is preferentially expressed by CD103(+) DCs, and confers the...
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| 出版年: | J Immunol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4992650/ https://ncbi.nlm.nih.gov/pubmed/27481847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600244 |
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