β8 integrin expression and activation of TGF-β by intestinal dendritic cells is determined by both tissue microenvironment and cell lineage

Activation of TGF-β by dendritic cells (DCs) expressing αvβ8 integrin is essential for the generation of intestinal regulatory T cells (Tregs) that in turn promote tolerance to intestinal antigens. We have recently shown that αvβ8 integrin is preferentially expressed by CD103(+) DCs, and confers the...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Boucard-Jourdin, Mathilde, Kugler, David, Ahanda, Marie-Laure Endale, This, Sébastien, De Calisto, Jaime, Zhang, Ailiang, Mora, J. Rodrigo, Stuart, Lynda M., Savill, John, Lacy-Hulbert, Adam, Paidassi, Helena
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992650/
https://ncbi.nlm.nih.gov/pubmed/27481847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600244
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