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Fusion competent synaptic vesicles persist upon active zone disruption and loss of vesicle docking

In a nerve terminal, synaptic vesicle docking and release are restricted to an active zone. The active zone is a protein scaffold that is attached to the presynaptic plasma membrane and opposed to postsynaptic receptors. Here, we generated conditional knockout mice removing the active zone proteins...

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Publicado en:Neuron
Autores principales: Wang, Shan Shan H., Held, Richard G., Wong, Man Yan, Liu, Changliang, Karakhanyan, Aziz, Kaeser, Pascal S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991631/
https://ncbi.nlm.nih.gov/pubmed/27537483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.07.005
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