Pre-treatment evaluation of 5-fluorouracil degradation rate: association of poor and ultra-rapid metabolism with severe toxicity in a colorectal cancer patients cohort

Despite the wide use of 5-fluorouracil-based chemotherapy, development of severe toxicity that follow the treatment is not a rare event. The efforts to establish pretreatment tools for toxicity prediction, led to the development of various pharmacogenetic and biochemical assays, mainly targeted to a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mazzuca, Federica, Borro, Marina, Botticelli, Andrea, Mazzotti, Eva, Marchetti, Luca, Gentile, Giovanna, La Torre, Marco, Lionetto, Luana, Simmaco, Maurizio, Marchetti, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991479/
https://ncbi.nlm.nih.gov/pubmed/26967565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7991
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