MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death. This high mortality has been commonly attributed to the presence of residual cancer stem cells (CSCs). Meanwhile, MEK1 signaling is regarded as a key molecular in HCC maintenance and development. However, nobody has figured o...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Cheng, Jiamin, Liu, Chungang, Liu, Limei, Chen, Xuejiao, Shan, Juanjuan, Shen, Junjie, Zhu, Wei, Qian, Cheng
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991478/
https://ncbi.nlm.nih.gov/pubmed/26967560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7972
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