Everolimus exhibits anti-tumorigenic activity in obesity-induced ovarian cancer

Everolimus inhibits mTOR kinase activity and its downstream targets by acting on mTORC1 and has anti-tumorigenic activity in ovarian cancer. Clinical and epidemiologic data find that obesity is associated with worse outcomes in ovarian cancer. In addition, obesity leads to hyperactivation of the mTO...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Guo, Hui, Zhong, Yan, Jackson, Amanda L., Clark, Leslie H., Kilgore, Josh, Zhang, Lu, Han, Jianjun, Sheng, Xiugui, Gilliam, Timothy P., Gehrig, Paola A., Zhou, Chunxiao, Bae, Victoria L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991459/
https://ncbi.nlm.nih.gov/pubmed/26959121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7934
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