Innate Invariant NKT Cell Recognition of HIV-1–Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion

Invariant NKT (iNKT) cells are innate-like T cells that respond rapidly with a broad range of effector functions upon recognition of glycolipid Ags presented by CD1d. HIV-1 carries Nef- and Vpu-dependent mechanisms to interfere with CD1d surface expression, indirectly suggesting a role for iNKT cell...

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Veröffentlicht in:J Immunol
Hauptverfasser: Paquin-Proulx, Dominic, Gibbs, Anna, Bächle, Susanna M., Checa, Antonio, Introini, Andrea, Leeansyah, Edwin, Wheelock, Craig E., Nixon, Douglas F., Broliden, Kristina, Tjernlund, Annelie, Moll, Markus, Sandberg, Johan K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2016
Schlagworte:
Infectious Disease and Host Response
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991248/
https://ncbi.nlm.nih.gov/pubmed/27481843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600556
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