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Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

Glucocorticoid-suppressible hyperaldosteronism (GSH) is an autosomal dominant form of familial hypertension. The biochemical abnormalities seen in this disorder may be remedied by administration of dexamethasone, implying that aldosterone synthesis is being abnormally regulated by corticotropin. The...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Pascoe, L, Curnow, K M, Slutsker, L, Connell, J M, Speiser, P W, New, M I, White, P C
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49911/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1518866/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.17.8327
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