Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

Glucocorticoid-suppressible hyperaldosteronism (GSH) is an autosomal dominant form of familial hypertension. The biochemical abnormalities seen in this disorder may be remedied by administration of dexamethasone, implying that aldosterone synthesis is being abnormally regulated by corticotropin. The...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Pascoe, L, Curnow, K M, Slutsker, L, Connell, J M, Speiser, P W, New, M I, White, P C
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49911/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1518866/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.17.8327
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