GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo

GNA13 is the most frequently mutated gene in germinal center (GC)-derived B-cell lymphomas, including nearly a quarter of Burkitt lymphoma and GC-derived diffuse large B-cell lymphoma. These mutations occur in a pattern consistent with loss of function. We have modeled the GNA13-deficient state excl...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Healy, Jane A., Nugent, Adrienne, Rempel, Rachel E., Moffitt, Andrea B., Davis, Nicholas S., Jiang, Xiaoyu, Shingleton, Jennifer R., Zhang, Jenny, Love, Cassandra, Datta, Jyotishka, McKinney, Matthew E., Tzeng, Tiffany J., Wettschureck, Nina, Offermanns, Stefan, Walzer, Katelyn A., Chi, Jen-Tsan, Rasheed, Suhail A. K., Casey, Patrick J., Lossos, Izidore S., Dave, Sandeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991089/
https://ncbi.nlm.nih.gov/pubmed/26989201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-659938
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