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ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling

Bone metastases occur in up to 70% of advanced breast cancer. For most patients with breast cancer, bone metastases are predominantly osteolytic. Interactions between tumor cells and stromal cells in the bone microenvironment drive osteolytic bone metastasis, a process that requires the activation o...

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Detalles Bibliográficos
Publicado en:Sci Signal
Main Authors: Wang, Jun, Rouse, Clay, Jasper, Jeff S., Pendergast, Ann Marie
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991033/
https://ncbi.nlm.nih.gov/pubmed/26838548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad3210
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