BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

Inhibition of prosurvival BCL2 family members can induce autophagy, but the mechanism is controversial. We have provided genetic evidence that BCL2 family members block autophagy by inhibiting BAX and BAK1, but others have proposed they instead inhibit BECN1. Here we confirm that small molecule BH3...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Reljic, Boris, Conos, Stephanie, Lee, Erinna F., Garnier, Jean-Marc, Dong, Li, Lessene, Guillaume, Fairlie, W. Douglas, Vaux, David L., Lindqvist, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990995/
https://ncbi.nlm.nih.gov/pubmed/27172402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1179406
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