Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation. In cGVHD, alloreactive T cells and germinal center (GC) B cells often participate in GC reactions to produce pathogenic antibodies. Although regulatory T cells (Tregs) can inhibit...

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Publicado en:Blood
Autores principales: McDonald-Hyman, Cameron, Flynn, Ryan, Panoskaltsis-Mortari, Angela, Peterson, Nicholas, MacDonald, Kelli P. A., Hill, Geoffrey R., Luznik, Leo, Serody, Jonathan S., Murphy, William J., Maillard, Ivan, Munn, David H., Turka, Laurence A., Koreth, John, Cutler, Corey S., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Blazar, Bruce R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2016
Materias:
Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990850/
https://ncbi.nlm.nih.gov/pubmed/27385791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-715896
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