Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

Chronic GVHD (cGVHD) poses a significant risk for HSCT patients. Preclinical development of new therapeutic modalities has been hindered by models with pathologic findings that may not simulate the development of human cGVHD. Previously, we have demonstrated that cGVHD induced by allogeneic HSCT aft...

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Autori principali: Srinivasan, Mathangi, Flynn, Ryan, Price, Andrew, Ranger, Ann, Browning, Jeffrey L., Taylor, Patricia A., Ritz, Jerome, Antin, Joseph H., Murphy, William J., Luznik, Leo, Shlomchik, Mark J., Panoskaltsis-Mortari, Angela, Blazar, Bruce R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286218/
https://ncbi.nlm.nih.gov/pubmed/22072556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-364414
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