Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-Predicted HIV Variants in the Berlin Patient

The “Berlin patient” is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependenc...

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Detalles Bibliográficos
Publicado en:Clin Infect Dis
Autores principales: Symons, Jori, Vandekerckhove, Linos, Hütter, Gero, Wensing, Annemarie M. J., van Ham, Petra M., Deeks, Steven G., Nijhuis, Monique
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
HIV/AIDS
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990826/
https://ncbi.nlm.nih.gov/pubmed/24759824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciu284
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