A novel sulindac derivative lacking COX-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model

Nonsteroidal anti-inflammatory drugs (NSAIDs) including sulindac are well-documented to be highly effective for cancer chemoprevention. However, their cyclooxygenase (COX) inhibitory activities cause severe gastrointestinal and cardiovascular toxicities, limiting their chronic use. Recent studies su...

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Veröffentlicht in:Cancer Prev Res (Phila)
Hauptverfasser: Zhang, Yong, Zhang, Jinhui, Wang, Lei, Quealy, Emily, Gary, Bernard D., Reynolds, Robert C., Piazza, Gary A., Lü, Junxuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990820/
https://ncbi.nlm.nih.gov/pubmed/20587701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-09-0273
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