Direct Detection and Quantification of Abasic Sites for In Vivo Studies of DNA Damage and Repair

Use of chemotherapeutic agents to induce cytotoxic DNA damage and programmed cell death is a key strategy in cancer treatments. However, the efficacy of DNA-targeted agents such as temozolomide is often compromised by intrinsic cellular responses such as DNA base excision repair (BER). Previous stud...

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Udgivet i:Nucl Med Biol
Main Authors: Wang, Yanming, Liu, Lili, Wu, Chunying, Bulgar, Alina, Somoza, Eduardo, Zhu, Wenxia, Gerson, Stanton L.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990785/
https://ncbi.nlm.nih.gov/pubmed/19875055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2009.07.007
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