A Novel PET Marker for In Vivo Quantification of Myelination

C-11-Labeled N-methyl-4,4′-diaminostilbene ([(11)C]MeDAS) was synthesized and evaluated as a novel radiotracer for in vivo microPET imaging of myelination. [(11)C]MeDAS exhibits optimal lipophilicity for brain uptake with a logPoct value of 2.25. Both in vitro and ex vivo staining exhibited MeDAS ac...

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Main Authors: Wu, Chunying, Wang, Changing, Popescu, Daniela, Zhu, Wenxia, Somoza, Eduardo, Zhu, Junqing, Condie, Allison G., Flask, Chris, Miller, Robert H., Macklin, Wendy, Wang, Yanming
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044472/
https://ncbi.nlm.nih.gov/pubmed/21071233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.10.018
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