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ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity

Scribble (SCRIB) is a tumor suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. Paradoxically, SCRIB is frequently amplified in human cancers, however, fails to localize properly to cell-cell junctions, suggesting that mislocalization of SCRIB contrib...

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Bibliografiske detaljer
Udgivet i:Nat Chem Biol
Main Authors: Chen, Baoen, Zheng, Baohui, DeRan, Micael, Jarugumilli, Gopala K., Fu, Jianjun, Brooks, Yang S., Wu, Xu
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990496/
https://ncbi.nlm.nih.gov/pubmed/27380321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2119
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