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Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins
The RNA Recognition Motif (RRM) is the largest family of eukaryotic RNA-binding proteins. Engineered RRMs with new specificity would provide valuable tools and an exacting test of our understanding of specificity. We have achieved the first successful re-design of the specificity of an RRM using rat...
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| Publicado en: | Nat Chem Biol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4990487/ https://ncbi.nlm.nih.gov/pubmed/27428511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2128 |
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