Bcl-2 family member Mcl-1 expression is reduced under hypoxia by the E3 ligase FBW7 contributing to BNIP3 induced cell death in glioma cells

Mcl-1 is an anti-apoptotic Bcl-2 family member that is often over-expressed in the malignant brain tumor glioblastoma (GBM). It has been previously shown that epidermal growth factor receptors up-regulate Mcl-1 contributing to a cell survival response. Hypoxia is a poor prognostic marker in glioblas...

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Veröffentlicht in:Cancer Biol Ther
Hauptverfasser: Chen, Yongqiang, Henson, Elizabeth S., Xiao, Wenyan, Shome, Epsita, Azad, Meghan B., Burton, Teralee R., Queau, Michelle, Sathya, Akshay, Eisenstat, David D., Gibson, Spencer B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990400/
https://ncbi.nlm.nih.gov/pubmed/26467103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1095399
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