Iron depletion enhances the effect of sorafenib in hepatocarcinoma

Human hepatocellular carcinoma (HCC) is known to have a poor prognosis. Sorafenib, a molecular targeted drug, is most commonly used for HCC treatment. However, its effect on HCC is limited in clinical use and therefore new strategies regarding sorafenib treatment are required. Iron overload is known...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Urano, Shinichi, Ohara, Toshiaki, Noma, Kazuhiro, Katsube, Ryoichi, Ninomiya, Takayuki, Tomono, Yasuko, Tazawa, Hiroshi, Kagawa, Shunsuke, Shirakawa, Yasuhiro, Kimura, Fumiaki, Nouso, Kazuhiro, Matsukawa, Akihiro, Yamamoto, Kazuhide, Fujiwara, Toshiyoshi
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990399/
https://ncbi.nlm.nih.gov/pubmed/27089255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1177677
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