Preclinical Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding of Sodium (±)-5-Bromo-2-(α-Hydroxypentyl) Benzoate (BZP), an Innovative Potent Anti-ischemic Stroke Agent

Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (BZP) is a potential cardiovascular drug and exerts potent neuroprotective effect against transient and long-term ischemic stroke in rats. BZP could convert into 3-butyl-6-bromo-1(3H)-isobenzofuranone (Br-NBP) in vitro and in vivo. However, the pharmac...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Tian, Xin, Li, Hong-Meng, Wei, Jing-Yao, Liu, Bing-Jie, Zhang, Yu-Hai, Wang, Gao-Ju, Chang, Jun-Biao, Qiao, Hai-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990024/
https://ncbi.nlm.nih.gov/pubmed/27588003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00255
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