Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting enzyme for GSH synthesis, are associated wit...

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Vydáno v:Schizophr Bull
Hlavní autoři: Xin, Lijing, Mekle, Ralf, Fournier, Margot, Baumann, Philipp S., Ferrari, Carina, Alameda, Luis, Jenni, Raoul, Lu, Huanxiang, Schaller, Benoit, Cuenod, Michel, Conus, Philippe, Gruetter, Rolf, Do, Kim Q.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988744/
https://ncbi.nlm.nih.gov/pubmed/27069063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbw038
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