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Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression

The Runt-related transcription factors (RUNX) are master regulators of development and major players in tumorigenesis. Interestingly, unlike most transcription factors, RUNX proteins are detected on the mitotic chromatin and apparatus, suggesting that they are functionally active in mitosis. Here, w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chuang, Linda Shyue Huey, Khor, Jian Ming, Lai, Soak Kuan, Garg, Shubham, Krishnan, Vaidehi, Koh, Cheng-Gee, Lee, Sang Hyun, Ito, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988568/
https://ncbi.nlm.nih.gov/pubmed/27217562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523157113
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