Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases

Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐menthol reductase and (−)‐menthone:(+)‐neomenthol reductase, and the “ene” reductase isopiperitenone reductase. We identified a rare catalytic residue substitution in the...

Full description

Saved in:
Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988501/
https://ncbi.nlm.nih.gov/pubmed/27411040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201603785
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items