Repair of a Mutation Disrupting the Guinea Pig Cytomegalovirus Pentameric Complex Acquired during Fibroblast Passage Restores Pathogenesis in Immune-Suppressed Guinea Pigs and in the Context of Congenital Infection

Guinea pig cytomegalovirus (GPCMV) provides a valuable model for congenital cytomegalovirus transmission. Salivary gland (SG)-passaged stocks of GPCMV are pathogenic, while tissue culture (TC) passage in fibroblasts results in attenuation. Nonpathogenic TC-derived virus N13R10 (cloned as a bacterial...

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Udgivet i:J Virol
Main Authors: McVoy, Michael A., Wang, Jian Ben, Dittmer, Dirk P., Bierle, Craig J., Swanson, Elizabeth C., Fernández-Alarcón, Claudia, Hernandez-Alvarado, Nelmary, Zabeli, Jason C., Schleiss, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988165/
https://ncbi.nlm.nih.gov/pubmed/27307567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00320-16
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