System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes

HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic process, and are misregulated in numerous diseases. Nonetheless, understanding of HECT E3s is limited by a paucity of selective and potent modulators. To overcome this challenge, we systematically developed...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Zhang, Wei, Wu, Kuen-Phon, Sartori, Maria A., Kamadurai, Hari B., Ordureau, Alban, Jiang, Chong, Mercredi, Peter Y., Murchie, Ryan, Hu, Jicheng, Persaud, Avinash, Mukherjee, Manjeet, Li, Nan, Doye, Anne, Walker, John R., Sheng, Yi, Hao, Zhenyue, Li, Yanjun, Brown, Kevin R., Lemichez, Emmanuel, Chen, Junjie, Tong, Yufeng, Harper, J. Wade, Moffat, Jason, Rotin, Daniela, Schulman, Brenda A., Sidhu, Sachdev S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988125/
https://ncbi.nlm.nih.gov/pubmed/26949039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.005
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