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PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP(61)

Phosphorylation regulates surface and synaptic expression of NMDA receptors (NMDARs). Both the tyrosine kinase Fyn and the tyrosine phosphatase striatal-enriched protein tyrosine phosphatase (STEP) are known to target the NMDA receptor subunit GluN2B on tyrosine 1472, which is a critical residue tha...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Won, Sehoon, Incontro, Salvatore, Nicoll, Roger A., Roche, Katherine W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987792/
https://ncbi.nlm.nih.gov/pubmed/27457929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609702113
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