ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis

Atopic dermatitis (AD) is the most common inflammatory skin disease with no well-delineated cause or effective cure. Here we show that the p53 family member p63, specifically the ΔNp63, isoform has a key role in driving keratinocyte activation in AD. We find that overexpression of ΔNp63 in transgeni...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Rizzo, J M, Oyelakin, A, Min, S, Smalley, K, Bard, J, Luo, W, Nyquist, J, Guttman-Yassky, E, Yoshida, T, De Benedetto, A, Beck, L A, Sinha, S, Romano, R-A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987726/
https://ncbi.nlm.nih.gov/pubmed/26768665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.162
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