Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain

Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the Erb...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kawasaki, Yuki, Sakimura, Ayaka, Park, Chul Min, Tomaru, Rika, Tanaka, Tomohiro, Ozawa, Tatsuhiko, Zhou, Yue, Narita, Kaori, Kishi, Hiroyuki, Muraguchi, Atsushi, Sakurai, Hiroaki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987620/
https://ncbi.nlm.nih.gov/pubmed/27531070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31502
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