Rapid quantification of underivatized amino acids in plasma by hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass-spectrometry

BACKGROUND: Amino acidopathies are a class of inborn errors of metabolism (IEM) that can be diagnosed by analysis of amino acids (AA) in plasma. Current strategies for AA analysis include cation exchange HPLC with post-column ninhydrin derivatization, GC-MS, and LC-MS/MS-related methods. Major drawb...

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Dettagli Bibliografici
Pubblicato in:J Inherit Metab Dis
Autori principali: Prinsen, Hubertus C. M. T., Schiebergen-Bronkhorst, B. G. M., Roeleveld, M. W., Jans, J. J. M., de Sain-van der Velden, M. G. M., Visser, G., van Hasselt, P. M., Verhoeven-Duif, N. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987396/
https://ncbi.nlm.nih.gov/pubmed/27099181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-016-9935-z
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