Quantitation of Cotinine and its Metabolites in Rat Plasma and Brain Tissue by Hydrophilic Interaction Chromatography Tandem Mass Spectrometry (HILIC-MS/MS)

In this work, we developed a sensitive method to quantify cotinine (COT), norcotinine (NCOT), trans-3′-hydroxycotinine (OHCOT) and cotinine-N-oxide (COTNO) in rat plasma and brain tissue, using solid phase extraction (SPE), hydrophilic interaction liquid chromatography (HILIC) and tandem mass spectr...

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Detalhes bibliográficos
Main Authors: Li, Pei, Beck, Wayne D., Callahan, Patrick M., Terry, Alvin V., Bartlett, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027976/
https://ncbi.nlm.nih.gov/pubmed/23022114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2012.09.018
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