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Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive pip...

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Pubblicato in:Cell Rep
Autori principali: Shlien, Adam, Raine, Keiran, Fuligni, Fabio, Arnold, Roland, Nik-Zainal, Serena, Dronov, Serge, Mamanova, Lira, Rosic, Andrej, Ju, Young Seok, Cooke, Susanna L., Ramakrishna, Manasa, Papaemmanuil, Elli, Davies, Helen R., Tarpey, Patrick S., Van Loo, Peter, Wedge, David C., Jones, David R., Martin, Sancha, Marshall, John, Anderson, Elizabeth, Hardy, Claire, Barbashina, Violetta, Aparicio, Samuel A.J.R., Sauer, Torill, Garred, Øystein, Vincent-Salomon, Anne, Mariani, Odette, Boyault, Sandrine, Fatima, Aquila, Langerød, Anita, Borg, Åke, Thomas, Gilles, Richardson, Andrea L., Børresen-Dale, Anne-Lise, Polyak, Kornelia, Stratton, Michael R., Campbell, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987284/
https://ncbi.nlm.nih.gov/pubmed/27498871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.028
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