A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma

BACKGROUND: Preclinical studies have shown synergy between radiation therapy and immunotherapy. However, in almost all preclinical models, radiation is delivered in single doses or short courses of high doses (hypofractionated radiation). By contrast in most clinical settings, radiation is delivered...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Crocenzi, Todd, Cottam, Benjamin, Newell, Pippa, Wolf, Ronald F., Hansen, Paul D., Hammill, Chet, Solhjem, Matthew C., To, Yue-Yun, Greathouse, Amy, Tormoen, Garth, Jutric, Zeljka, Young, Kristina, Bahjat, Keith S., Gough, Michael J., Crittenden, Marka R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986363/
https://ncbi.nlm.nih.gov/pubmed/27532020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0149-6
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