A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma

BACKGROUND: Preclinical studies have shown synergy between radiation therapy and immunotherapy. However, in almost all preclinical models, radiation is delivered in single doses or short courses of high doses (hypofractionated radiation). By contrast in most clinical settings, radiation is delivered...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Crocenzi, Todd, Cottam, Benjamin, Newell, Pippa, Wolf, Ronald F., Hansen, Paul D., Hammill, Chet, Solhjem, Matthew C., To, Yue-Yun, Greathouse, Amy, Tormoen, Garth, Jutric, Zeljka, Young, Kristina, Bahjat, Keith S., Gough, Michael J., Crittenden, Marka R.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986363/
https://ncbi.nlm.nih.gov/pubmed/27532020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0149-6
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