CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway

BACKGROUND: Triple-negative breast cancer (TNBC) lacks specific therapeutic target and limits to chemotherapy and is essential to develop novel therapeutic regimens. Increasing studies indicated that tamoxifen, a selective estrogen receptor modulators (SERMs), has anti-tumor therapeutic effect in es...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Wu, Sheng-Tang, Sun, Guang-Huan, Cha, Tai-Lung, Kao, Chien-Chang, Chang, Sun-Yran, Kuo, Sheng-Chu, Way, Tzong-Der
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986227/
https://ncbi.nlm.nih.gov/pubmed/27526942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-016-0275-y
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