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Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and In-vitro Anti-breast Cancer Agents

A new group of 4-(Imidazolylmethyl)quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitroanti breast cancer agents. In-vitro COX-1 and COX-2 inhibition studies showed t...

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Foilsithe in:Iran J Pharm Res
Main Authors: Ghodsi, Razieh, Azizi, Ebrahim, Zarghi, Afshin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Shaheed Beheshti University of Medical Sciences 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986100/
https://ncbi.nlm.nih.gov/pubmed/27610157
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