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Adaptation in protein fitness landscapes is facilitated by indirect paths

The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double mutants, or a combinatorially complete subgraph in...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Wu, Nicholas C, Dai, Lei, Olson, C Anders, Lloyd-Smith, James O, Sun, Ren
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985287/
https://ncbi.nlm.nih.gov/pubmed/27391790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16965
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