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High‐throughput identification of protein mutant stability computed from a double mutant fitness landscape
The effect of a mutation on protein stability is traditionally measured by genetic construction, expression, purification, and physical analysis using low‐throughput methods. This process is tedious and limits the number of mutants able to be examined in a single study. In contrast, functional fitne...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815338/ https://ncbi.nlm.nih.gov/pubmed/26540565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2840 |
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