Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase

The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Cocchiarella, Fabienne, Latella, Maria Carmela, Basile, Valentina, Miselli, Francesca, Galla, Melanie, Imbriano, Carol, Recchia, Alessandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985251/
https://ncbi.nlm.nih.gov/pubmed/27574698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.38
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